pubmed: meniscus and stem ce...
NCBI: db=pubmed; Term=meniscus and stem cell treatment
NCBI pubmed
  • Sonographically Guided Knee Meniscus Injections: Feasibility, Techniques and Validation.
    Related Articles

    Sonographically Guided Knee Meniscus Injections: Feasibility, Techniques and Validation.

    PM R. 2017 Jan 13;:

    Authors: Baria MR, Sellon JL, Lueders D, Smith J

    Abstract
    BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described.
    OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus.
    DESIGN: Prospective, cadaveric laboratory investigation.
    SETTING: Academic institution procedural skills laboratory.
    SUBJECTS: Five unenbalmed cadaveric knee-ankle-foot specimens from 5 donors (3 female and 2 male) ages 33-92 years (mean age 74 years) with body mass indices of 21.1-32.4 kg/m(2) (mean 24.1 kg/m(2)).
    METHODS: A single, experienced operator completed SG injections into the bodies and posterior horns of the medial and lateral menisci of 5 unenbalmed cadaveric knees using colored latex and a 22-gauge, 38-millimeter needle. Following injection, co-investigators dissected each specimen to assess latex distribution within the menisci and identify injury to intra-articular and peri-articular structures.
    MAIN OUTCOME MEASURES: Latex location within the target region of meniscus (accurate/inaccurate), and iatrogenic injury to "at risk" intra- and peri-articular structures (present/absent).
    RESULTS: Seventeen of 20 injections were accurate. Two of 3 inaccurate injections infiltrated the posterior horn of the medial meniscus instead of the targeted meniscal body. One inaccurate lateral meniscus injection did not contain latex despite sonographically accurate needle placement. No specimen exhibited injury to regional neurovascular structures or intra-articular hyaline cartilage.
    CONCLUSIONS: SG meniscus injections are feasible and can accurately and safely deliver injectates such as regenerative agents into bodies and posterior horns of the medial and lateral menisci. The role of SG intrameniscal injections in the treatment of patients with degenerative and traumatic meniscal disorders warrants further exploration.

    PMID: 28093371 [PubMed - as supplied by publisher]

pubmed: meniscus and stem ce...
NCBI: db=pubmed; Term=meniscus and stem cell treatment
NCBI pubmed
  • Sonographically Guided Knee Meniscus Injections: Feasibility, Techniques and Validation.
    Related Articles

    Sonographically Guided Knee Meniscus Injections: Feasibility, Techniques and Validation.

    PM R. 2017 Jan 13;:

    Authors: Baria MR, Sellon JL, Lueders D, Smith J

    Abstract
    BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described.
    OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus.
    DESIGN: Prospective, cadaveric laboratory investigation.
    SETTING: Academic institution procedural skills laboratory.
    SUBJECTS: Five unenbalmed cadaveric knee-ankle-foot specimens from 5 donors (3 female and 2 male) ages 33-92 years (mean age 74 years) with body mass indices of 21.1-32.4 kg/m(2) (mean 24.1 kg/m(2)).
    METHODS: A single, experienced operator completed SG injections into the bodies and posterior horns of the medial and lateral menisci of 5 unenbalmed cadaveric knees using colored latex and a 22-gauge, 38-millimeter needle. Following injection, co-investigators dissected each specimen to assess latex distribution within the menisci and identify injury to intra-articular and peri-articular structures.
    MAIN OUTCOME MEASURES: Latex location within the target region of meniscus (accurate/inaccurate), and iatrogenic injury to "at risk" intra- and peri-articular structures (present/absent).
    RESULTS: Seventeen of 20 injections were accurate. Two of 3 inaccurate injections infiltrated the posterior horn of the medial meniscus instead of the targeted meniscal body. One inaccurate lateral meniscus injection did not contain latex despite sonographically accurate needle placement. No specimen exhibited injury to regional neurovascular structures or intra-articular hyaline cartilage.
    CONCLUSIONS: SG meniscus injections are feasible and can accurately and safely deliver injectates such as regenerative agents into bodies and posterior horns of the medial and lateral menisci. The role of SG intrameniscal injections in the treatment of patients with degenerative and traumatic meniscal disorders warrants further exploration.

    PMID: 28093371 [PubMed - as supplied by publisher]