muscular dystrophy stem cell treatmentmuscular dystrophy therapy

pubmed: muscular dystrophy a...
NCBI: db=pubmed; Term=muscular dystrophy and Stem Cell Therapy
NCBI pubmed
  • Making muscle: skeletal myogenesis in vivo and in vitro.
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    Making muscle: skeletal myogenesis in vivo and in vitro.

    Development. 2017 Jun 15;144(12):2104-2122

    Authors: Chal J, Pourquié O

    Abstract
    Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders. Understanding the mechanisms that drive skeletal muscle formation will not only help to unravel the molecular basis of skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs). PSCs have become an important tool for probing developmental questions, while differentiated cell types allow the development of novel therapeutic strategies. In this Review, we provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how this knowledge has been applied to differentiate PSCs into muscle fibers and their progenitors in vitro.

    PMID: 28634270 [PubMed - in process]

pubmed: muscular dystrophy a...
NCBI: db=pubmed; Term=muscular dystrophy and Stem Cell Treatment
NCBI pubmed
  • An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma.
    Related Articles

    An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma.

    Stem Cells Int. 2017;2017:2480375

    Authors: Hron AJ, Asakura A

    Abstract
    Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.

    PMID: 28638414 [PubMed - in process]