kidney stem cell therapyKidney and stem cell treatment

pubmed: kidney failure and s...
NCBI: db=pubmed; Term=kidney failure and stem cell therapy
NCBI pubmed
  • Regenerative strategies for kidney engineering.
    Related Articles

    Regenerative strategies for kidney engineering.

    FEBS J. 2016 Sep;283(18):3303-24

    Authors: Montserrat N, Garreta E, Izpisua Belmonte JC

    Abstract
    The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an immune regulator and modulator of cardiovascular physiology. The development of in vitro renal disease models with pluripotent stem cells (both human embryonic stem cells and induced pluripotent stem cells) and the generation of robust protocols for in vitro derivation of renal-specific-like cells from patient induced pluripotent stem cells have just emerged. Here we review major findings in the field of kidney regeneration with a major focus on the development of stepwise protocols for kidney cell production from human pluripotent stem cells and the latest advances in kidney bioengineering (i.e. decellularized kidney scaffolds and bioprinting). The possibility of generating renal-like three-dimensional structures to be recellularized with renal-derived induced pluripotent stem cells may offer new avenues to develop functional kidney grafts on-demand.

    PMID: 26938311 [PubMed - indexed for MEDLINE]

pubmed: kidney failure and s...
NCBI: db=pubmed; Term=kidney failure and stem cell treatment
NCBI pubmed
  • Regenerative strategies for kidney engineering.
    Related Articles

    Regenerative strategies for kidney engineering.

    FEBS J. 2016 Sep;283(18):3303-24

    Authors: Montserrat N, Garreta E, Izpisua Belmonte JC

    Abstract
    The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an immune regulator and modulator of cardiovascular physiology. The development of in vitro renal disease models with pluripotent stem cells (both human embryonic stem cells and induced pluripotent stem cells) and the generation of robust protocols for in vitro derivation of renal-specific-like cells from patient induced pluripotent stem cells have just emerged. Here we review major findings in the field of kidney regeneration with a major focus on the development of stepwise protocols for kidney cell production from human pluripotent stem cells and the latest advances in kidney bioengineering (i.e. decellularized kidney scaffolds and bioprinting). The possibility of generating renal-like three-dimensional structures to be recellularized with renal-derived induced pluripotent stem cells may offer new avenues to develop functional kidney grafts on-demand.

    PMID: 26938311 [PubMed - indexed for MEDLINE]